Anti-HAS2 Antibody (Center)

About this product

Boster Bio Anti-HAS2 Antibody (Center) (Catalog # M03375) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M03375-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity) .

Synonyms

Hyaluronan synthase 2, 2.4.1.212, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2

Gene Name

HAS2

UniProt

Q92819

Host

Mouse

Reactivity

Human

Immunogen

This HAS2 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 133-166 amino acids from the Central region of human HAS2.

Clonality

Monoclonal

Clone

Clone: 2105CT879.18.75

Tissue Specificity

Expressed in fibroblasts.

Applications

WB

Field of Research

Cardiovascular, Developmental Biology, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

2050798532993960233031912122827387984772122827320507985

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

63566 Da

Applications Notes

WB: 1:8000

Subcellular Location

Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi- pass membrane protein. Vesicle. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles (PubMed:30394292) . Post-translational modifications control HAS2 trafficking (PubMed:30394292) .

Prediction Reactivity

Human

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.