Anti-PAR4 PAWR Monoclonal Antibody

About this product

Boster Bio Anti-PAR4 PAWR Monoclonal Antibody catalog # M03637. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

M03637

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Par-4; PAWR; PAR4

Gene Name

PAWR

UniProt

Q96IZ0

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of PAR4 (aa1-330) expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 3G9H7 / 4H12E9

Tissue Specificity

Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.

Applications

WB, IHC, IF, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

36568 MW

Gene Name Synonym

PRKC apoptosis WT1 regulator protein

Subcellular Location

Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity) . Nuclear localization includes nucleoplasm and PML nuclear bodies. .

Protein Name

PRKC apoptosis WT1 regulator protein

Isotype

IgG

Contents

Ascitic fluid containing 0.03% sodium azide.