Anti-HSD17B10 Antibody (Center)

About this product

Boster Bio Anti-HSD17B10 Antibody (Center) (Catalog # M03844-1) . Tested in WB, Flow Cytometry, IHC-P, IF application (s) . This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M03844-1-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) .

Synonyms

3-hydroxyacyl-CoA dehydrogenase type-2, 1.1.1.35, 17-beta-hydroxysteroid dehydrogenase 10, 17-beta-HSD 10, 1.1.1.51, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 1.1.1.178, 3-hydroxyacyl-CoA dehydrogenase type II, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, HSD17B10, ERAB, HADH2, MRPP2, SCHAD, XH98G2

Gene Name

HSD17B10

UniProt

Q99714

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This HSD17B10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 140-172 amino acids from the Central region of human HSD17B10.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.

Applications

WB, Flow Cytometry, IHC-P, IF

Field of Research

Metabolism, Neuroscience, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

26923 Da

Subcellular Location

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid

Prediction Reactivity

Bovine

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.