Anti-SNW1 Antibody (C-Term)

About this product

Boster Bio Anti-SNW1 Antibody (C-Term) (Catalog # M03854) . Tested in WB, IF application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

M03854-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR) - and vitamin D receptor (VDR) -dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

Synonyms

SNW domain-containing protein 1, Nuclear protein SkiP, Nuclear receptor coactivator NCoA-62, Ski-interacting protein, SNW1, SKIIP, SKIP

Gene Name

SNW1

UniProt

Q13573

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SNW1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 464-497 amino acids from human SNW1.

Clonality

Polyclonal

Applications

WB, IF

Field of Research

Viral process, Host-Virus Interaction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

119916382850277028076346

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

61494 Da

Subcellular Location

Nucleus

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.