Anti-CAMK2 beta Antibody (C-term)

About this product

Boster Bio Anti-CAMK2 beta Antibody (C-term) (Catalog # M03964-1) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M03964-1-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+) /calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca (2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca (2+) transport and in fast-twitch muscle participates in the control of Ca (2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Synonyms

Calcium/calmodulin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta, 2.7.11.17, CAMK2B, CAM2, CAMK2, CAMKB

Gene Name

CAMK2B

UniProt

Q13554

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

This CAMK2 beta antibody is generated from a mouse immunized with a recombinant protein between 1-503 amino acids from human CAMK2 beta.

Clonality

Monoclonal

Clone

Clone: 1050CT14.1.3

Tissue Specificity

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Applications

WB, IHC-P

Field of Research

Cancer, Cardiovascular, Cell Biology, Metabolism, Neuroscience, Signal Transduction, Anti-Wnt-Pathway (plus Lgr5) Antibodies, Inflammation

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

16690701291000891669070131930741

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

72678 Da

Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Synapse {ECO:0000250|UniProtKB:P08413} Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR

Isotype

IgG1

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.