Anti-RBCK1 (UBCE7IP3) Antibody

About this product

Boster Bio Anti-RBCK1 (UBCE7IP3) Antibody (Catalog # M04562) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M04562-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF- RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Synonyms

RanBP-type and C3HC4-type zinc finger-containing protein 1, 6.3.2.-, HBV-associated factor 4, Heme-oxidized IRP2 ubiquitin ligase 1, HOIL-1, Hepatitis B virus X-associated protein 4, RING finger protein 54, Ubiquitin-conjugating enzyme 7-interacting protein 3, RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4

Gene Name

RBCK1

UniProt

Q9BYM8

Host

Mouse

Reactivity

Human

Immunogen

This RBCK1 (UBCE7IP3) antibody is generated from a mouse immunized with a recombinant protein of human RBCK1 (UBCE7IP3) .

Clonality

Monoclonal

Clone

Clone: 1839CT718.19.54

Applications

WB

Field of Research

Cell Biology, Viral process, Host-Virus Interaction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

12629548174494681871144812629548174494681871144817006537214551732145518021455181191369681700653721455173214551802145518119136968170065372145517321455180214551811700653721455173214551802145518119136968284813312848133128481331237089982000584621455181

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

57572 Da

Applications Notes

WB: 1:2000

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.