Anti-Ephrin type-B receptor 3 EphB3 Monoclonal Antibody

About this product

Boster Bio Anti-Ephrin type-B receptor 3 EphB3 Monoclonal Antibody catalog # M04659. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

M04659

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Ephrin type-B receptor 3;2.7.10.1; EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; Tyrosine-protein kinase TYRO6; EPHB3; ETK2, HEK2, TYRO6

Gene Name

EPHB3

UniProt

P54753

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of EphB3 (aa39-212) expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 4A122D1

Tissue Specificity

Ubiquitous.

Applications

WB, IHC, IF, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

110330 MW

Gene Name Synonym

Ephrin type-B receptor 3

Subcellular Location

Cell membrane

Protein Name

Ephrin type-B receptor 3

Isotype

IgG

Contents

Ascitic fluid containing 0.03% sodium azide.