Anti-KANK1 Antibody

About this product

Boster Bio Anti-KANK1 Antibody (Catalog # M05029) . Tested in WB, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

M05029-200ul

Size / count

200 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Synonyms

KN motif and ankyrin repeat domain-containing protein 1, Ankyrin repeat domain-containing protein 15, Kidney ankyrin repeat-containing protein, KANK1, ANKRD15, KANK, KIAA0172

Gene Name

KANK1

UniProt

Q14678

Host

Mouse

Reactivity

Human

Immunogen

This KANK1 antibody is generated from a mouse immunized with a recombinant protein of human KANK1.

Clonality

Monoclonal

Clone

Clone: 1773CT634.49.61

Tissue Specificity

Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.

Applications

WB, IHC-P

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

147289 Da

Subcellular Location

Cell projection, ruffle membrane. Cytoplasm. Nucleus Note=Colocalizes with KIF21A in membrane ruffles (PubMed:19559006) Shuttles between the cytoplasm and nucleus (PubMed:16968744) [Isoform 2]: Cytoplasm. Nucleus Note=Shuttles between the cytoplasm and nucleus

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.