Anti-RAB21 Antibody

About this product

Boster Bio Anti-RAB21 Antibody (Catalog # M05683) . Tested in WB application (s) . This antibody reacts with Human, African green monkey.

Specifications

Catalog number

M05683-200ul

Size / count

200 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity) . During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity) .

Synonyms

Ras-related protein Rab-21, RAB21, KIAA0118

Gene Name

RAB21

UniProt

Q9UL25

Host

Mouse

Reactivity

Human, African green monkey

Immunogen

This RAB21 antibody is generated from a mouse immunized with a recombinant protein between 1-225 amino acids from the human RAB21.

Clonality

Monoclonal

Clone

Clone: 1701CT536.68.39

Tissue Specificity

Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.

Applications

WB

Field of Research

Cancer, Cell Biology, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

1880443525648148188044352564814831455601

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

24348 Da

Applications Notes

WB: 1:2000

Subcellular Location

Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Cell projection, neuron projection {ECO:0000250|UniProtKB:P35282}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity) . In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961) . During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435) . In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435) {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:10887961, ECO:0000269|PubMed:18804435}

Isotype

IgG2b, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.