Anti-PSMA5 Antibody

About this product

Boster Bio Anti-PSMA5 Antibody (Catalog # M07499) . Tested in WB, IF, IHC-P application (s) . This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M07499-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.

Synonyms

Proteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5

Gene Name

PSMA5

UniProt

P28066

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Purified His-tagged PSMA5 protein (Fragment) was used to produced this monoclonal antibody.

Clonality

Monoclonal

Clone

Clone: 426CT8.5.1

Tissue Specificity

Expressed in fetal brain (at protein level) .

Applications

WB, IF, IHC-P

Field of Research

Cell Biology, Proteasome

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

26411 Da

Subcellular Location

Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9

Prediction Reactivity

Bovine

Isotype

IgG1

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.