Anti-PSMA5 Antibody

About this product

Boster Bio Anti-PSMA5 Antibody (Catalog # M07499-1) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M07499-1-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Synonyms

Proteasome subunit alpha type-5, 3.4.25.1, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5

Gene Name

PSMA5

UniProt

P28066

Host

Mouse

Reactivity

Human

Immunogen

This PSMA5 antibody is generated from a mouse immunized with a recombinant protein between 1-241 amino acids from human PSMA5.

Clonality

Monoclonal

Clone

Clone: 426CT32.1.2

Tissue Specificity

Expressed in fetal brain (at protein level) .

Applications

WB

Field of Research

Cell Biology, Proteasome

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

26411 Da

Applications Notes

WB: 1:4000

Subcellular Location

Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9

Prediction Reactivity

Bovine, Mouse

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.