Anti-Human IgG2 IGHG2 Rabbit Monoclonal Antibody, Clone#RM118

About this product

Boster Bio Anti-Human IgG2 IGHG2 Rabbit Monoclonal Antibody, Clone#RM118 (Catalog # M07865) . Tested in ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

M07865

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Immunoglobulin heavy constant gamma 2 ; Ig gamma-2 chain C region ; Ig gamma-2 chain C region DOT ; Ig gamma-2 chain C region TIL ; Ig gamma-2 chain C region ZIE ; IGHG2

Gene Name

IGHG2

UniProt

P01859

Host

Rabbit

Reactivity

Human

Cross Reactivity

Reacts to the heavy chain of human IgG2. RM118 does not cross-react to other IgG subclasses (IgG1, IgG3, IgG4), and shows no cross-reactivity to IgM, IgA, IgD, or IgE. RM118 does not react to monkey (Cyno or Rhesus) IgG, mouse IgG, rat IgG, or goat IgG.

Immunogen

Human IgG2

Clonality

Monoclonal

Clone

Clone: RM118

Applications

ELISA

Field of Research

Immunoglobulins, Immunology

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

1 mg/mL

Form

Liquid

Function

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) .

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

35901 MW

Gene Name Synonym

Immunoglobulin heavy constant gamma 2

Subcellular Location

Secreted. Cell membrane.

Isotype

Rabbit IgG

Contents

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide