Anti-Hu CD112 Purified NECTIN2 Monoclonal Antibody

About this product

Boster Bio Anti-Hu CD112 Purified NECTIN2 Monoclonal Antibody (Catalog# M08081) . Tested in Flow Cytometry, IP, IHC-F application (s) . This antibody reacts with Human.

Specifications

Catalog number

M08081

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD112, also known as nectin-2, is a transmembrane glycoprotein involved in organization of adherens junctions. It also serves as a target molecule for entry of certain strains of herpes simplex virus (HSV) and pseudorabies virus (PRV) . It is homologous to CD155, which serves as a target molecule for polio virus. CD112 seems to play a role in neural tube formation, with N-cadherin. Inside the cell, CD112 is connected with actin cytoskeleton through afadin. Variations in the CD112 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Synonyms

NECTIN2, HVEB, PRR2, PVRL2, PVRR2

Gene Name

NECTIN2

UniProt

Q92692

Host

Mouse

Reactivity

Human

Immunogen

NIH/3T3 cells transfected with human Nectin-2. The mouse monoclonal antibody R2.525 recognizes an extracellular epitope on CD112, a type I transmembrane glycoprotein expressed by myelomonocytic and megakaryocytic cells, and by CD34+ hematopoietic progenitors.

Clonality

Monoclonal

Clone

Clone: R2.525

Tissue Specificity

Ubiquitous.

Applications

Flow Cytometry, IP, IHC-F

Purification

Purified by protein-A affinity chromatography.

Concentration

1 mg/mL

Form

Liquid

Function

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705) . Probable cell adhesion protein (PubMed:9657005) .

Storage Conditions

Store at 2-8°C. Do not freeze.

Observed Molecular Weight

57742 MW

Applications Notes

Flow cytometry: 1-4 μg/mL.

Gene Name Synonym

Nectin cell adhesion molecule 2

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

Nectin-2

Isotype

Mouse IgG1 kappa

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide