Anti-MKRN2 Antibody

About this product

Boster Bio Anti-MKRN2 Antibody (Catalog # M10562) . Tested in WB, Flow Cytometry, IHC-P, IF application (s) . This antibody reacts with Human.

Specifications

Catalog number

M10562-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Synonyms

Probable E3 ubiquitin-protein ligase makorin-2, 632-, RING finger protein 62, MKRN2, RNF62

Gene Name

MKRN2

UniProt

Q9H000

Host

Mouse

Reactivity

Human

Immunogen

This MKRN2 antibody is generated from a mouse immunized with recombinant protein.

Clonality

Monoclonal

Clone

Clone: 1556CT631.230.55.49

Tissue Specificity

Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level) (PubMed:28008940) . Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen (PubMed:11597136) .

Applications

WB, Flow Cytometry, IHC-P, IF

Field of Research

Cell Biology, Neuroscience

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) . Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity) . Plays a role in the regulation of spermiation and in male fertility (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

46940 Da

Subcellular Location

Cytoplasm {ECO:0000250|UniProtKB:Q9ERV1}. Nucleus {ECO:0000250|UniProtKB:Q9ERV1}

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.