Anti-BIN3 Monoclonal Antibody

About this product

Boster Bio Anti-BIN3 Monoclonal Antibody (Catalog # M11817) . Tested in ELISA, WB applications. This antibody reacts with Mouse.

Specifications

Catalog number

M11817

Size / count

100 µg

Dry ice

Yes

Hazardous

No

Discontinued

No

Background

BIN-3 encodes an evolutionarily conserved and ubiquitously expressed member of the BAR superfamily of curved membrane and GTPase-binding proteins implicated in signal transduction and vesicular trafficking. In humans, Bin3 maps to chromosome 8p21.3, a region widely implicated in cancer suppression that is often deleted in non–Hodgkin’s lymphomas and various epithelial tumors. Study in mouse suggests that homozygous inactivation of Bin3 causes cataracts and an increased susceptibility to lymphomas during aging.

Synonyms

BIN3, Bridging integrator 3, BIN-3, BIN 3, BIN3, anti-BIN-3

Gene Name

BIN3

UniProt

Q9NQY0

Host

Mouse

Reactivity

Mouse

Immunogen

Anti-BIN3 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with a full length human BIN3 recombinant protein followed by hybridoma development.

Clonality

Monoclonal

Clone

Clone: Clone: 3A4

Tissue Specificity

Ubiquitously expressed except in brain.

Applications

ELISA, IP, WB

Field of Research

Actin Assembly, Actin, etc., Cell Biology, Cell Cycle, Cell Division, Cytokinesis, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Anti-BIN3 was purified from clarified mouse ascetic fluid by Protein A chromatography followed by extensive dialysis against the buffer stated above. BIN3 antibody is specific for human BIN3 protein. A BLAST analysis was used to suggest cross-reactivity with BIN3 from human and mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with BIN3 from other sources has not been determined.

Concentration

1.0 mg/mL by UV absorbance at 280 nm

Form

Liquid (sterile filtered)

Function

Involved in cytokinesis and septation where it has a role in the localization of F-actin.

Shipping Conditions

Dry Ice Shipping

Storage Conditions

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Observed Molecular Weight

29665 MW

Gene Name Synonym

Bridging integrator 3

Subcellular Location

Cytoplasm, cytoskeleton.

Isotype

IgG1

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide