Anti-RAB7L1 Antibody

About this product

Boster Bio Anti-RAB7L1 Antibody (Catalog # M30753) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M30753-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans- Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system ( CNS) . May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.

Synonyms

Ras-related protein Rab-7L1, Rab-7-like protein 1, Ras-related protein Rab-29, RAB29, RAB7L1

Gene Name

RAB29

UniProt

O14966

Host

Mouse

Reactivity

Human

Immunogen

This RAB7L1 antibody is generated from a mouse immunized with a recombinant protein of human RAB7L1.

Clonality

Monoclonal

Clone

Clone: 1789CT823.71.1.1

Tissue Specificity

Ubiquitous.

Applications

WB

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

24788816247888162921281522042847

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

23155 Da

Applications Notes

WB: 1:1000-1:2000

Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815) Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847) Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847) . Colocalizes with TGN46 at the trans- Golgi network (TGN) (PubMed:24788816) . In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847) .

Isotype

IgG1

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.