Anti-Phospho CNOT2 (Ser101) Antibody

About this product

Boster Bio Anti-Phospho CNOT2 (Ser101) Antibody (Catalog# P06400) . Tested in IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

P06400

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

CNOT2; CDC36; NOT2; HSPC131; MSTP046; CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2

Gene Name

CNOT2

UniProt

Q9NZN8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human CNOT2 around the phosphorylation site of Ser101. Immunogen sequence location: 67-116

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.

Applications

IHC, ICC, IF, ELISA

Field of Research

Epigenetics and Nuclear Signaling, Mediator Complex, Transcription

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Sensitivity

<15pg/ml

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

59738 MW

Gene Name Synonym

CCR4-NOT transcription complex subunit 2

Subcellular Location

Cytoplasm. Nucleus.

Isotype

Rabbit IgG

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.