P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R]

Catalog number HA601312

Price for HA601312

Size / count 100 µL

About this product

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances. Substrate enters P-gp either from an opening within the inner leaflet of the membrane or from an opening at the cytoplasmic side of the protein. ATP binds at the cytoplasmic side of the protein. Following binding of each, ATP hydrolysis shifts the substrate into a position to be excreted from the cell. Release of the phosphate (from the original ATP molecule) occurs concurrently with substrate excretion. ADP is released, and a new molecule of ATP binds to the secondary ATP-binding site. Hydrolysis and release of ADP and a phosphate molecule resets the protein, so that the process can start again.

Specifications

Catalog number: HA601312
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: ABC20 antibody ABCB1 antibody ATP binding cassette, sub family B (MDR/TAP), member 1 antibody ATP-binding cassette sub-family B member 1 antibody CD243 antibody CLCS antibody Colchicin sensitivity antibody Doxorubicin resistance antibody GP170 antibody MDR1 antibody MDR1_HUMAN antibody Multidrug resistance 1 antibody Multidrug resistance protein 1 antibody P glycoprotein 1 antibody P gp antibody P-glycoprotein 1 antibody PGY1 antibody
Abbreviation: ABCB1, MDR1, PGY1
Swiss Prot: P08183 Human, P06795 Mouse, P43245 Rat
Cellular Locus: Cell membrane, Apical cell membrane, Cytoplasm.
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human P Glycoprotein aa 935-1,280 / 1,280.
Isotype: IgG1
Clone: A10E12-R
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: IHC-P
Positive Control: Human colon cancer tissue, human liver cancer tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue.
Concentration: 1 mg/mL
Dilution: IHC-P: 1:5,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 142 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R]?

The catalog number for P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R] is HA601312.

What sizes are available for P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R]?

P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R] is available in the following size(s): 100 µL.

Is P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R] in stock?

P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R] is currently made to order / not held in immediate stock. Contact us for lead time.

What is P Glycoprotein Recombinant Mouse Monoclonal Antibody [A10E12-R] used for?

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.