Monoclonal Antibody to TLR6 (Clone: ABM1B50)

About this product

TLR6 (Toll-Like Receptors 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 forms heterodimers with TLR1 and TLR2, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 in co-operation with TLR6 trigger inflammatory responses via activation of NF-kappaB, which regulates the transcription of inflammatory molecules. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles) -induced inflammatory responses. Upon silencing, TLR6 significantly inhibited the pro-inflammatory cytokine levels, reactive nitrogen species generation and inducible nitric oxide synthase expression.

Specifications

Catalog number

10-3002-25

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Product Name Alternative

TLR6

Gene Name

TLR6

Gene ID

10333

UniProt

Q9Y2C9

Host

Mouse

Reactivity

Human

Immunogen

A partial length recombinant TLR6 protein (amino acids 280-512) was used as the immunogen for this antibody.

Target Antigen

TLR6

Clonality

Monoclonal

Clone

ABM1B50

Applications

FACS, WB

Purification

Protein G Chromatography

Format

Purified

Components

25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

Western blot analysis: 2-4 μg/mL; FACS analysis: 0.5-1 μg/10^6 cells

Isotype

Mouse IgG1 Kappa