Monoclonal Antibody to TLR3 (Clone: ABM15D5)

About this product

TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.

Specifications

Catalog number

10-3004-25

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Product Name Alternative

TLR3

Gene Name

TLR3

Gene ID

7098

UniProt

O15455

Host

Mouse

Reactivity

Human

Immunogen

A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.

Target Antigen

TLR3

Clonality

Monoclonal

Clone

ABM15D5

Applications

FACS

Purification

Protein G Chromatography

Format

Purified

Components

25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

FACS analysis: 2.0 μg/10^6 cells

Isotype

Mouse IgG1 Kappa