Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96]

Catalog number HA721915

Price for HA721915

Size / count 100 µL

About this product

Neurogranin is a small neuronal protein that binds to calmodulin in the absence of Ca2+ . Calmodulin binds Ca2+ and acts as a Ca2+ sensor to drive Ca2+-dependent signal transduction pathways by modulating its interaction with various kinases and phosphatases. In the postsynaptic compartment of the neuron, Ca2+ is carefully regulated and is a critical regulator of synaptic function and plasticity . Neurogranin is primarily expressed in the brain and is enriched in somato-dendritic compartments of projection neurons in various regions of the brain. Postsynaptically-enriched neurogranin likely influences Ca2+ or Ca2+/calmodulin-dependent neuronal functions, including synaptic plasticity, by binding to and releasing calmodulin in a Ca2+-dependent manner. Genetic variants in the gene encoding neurogranin, NRGN, are linked to several neuropsychiatric diseases, including schizophrenia . Interestingly, increase in cerebrospinal fluid neurogranin is correlated with neurodegenerative disease progression, which suggests that neurogranin could act as a biomarker for diseases like Alzheimer’s disease .

Specifications

Catalog number: HA721915
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Protein kinase C substrate RC3 antibody Calmodulin binding protein antibody Hng antibody NEUG (55-78) antibody NEUG_HUMAN antibody Neurogranin (protein kinase C substrate) antibody Ng antibody NRGN antibody Protein kinase C substrate antibody RC3 antibody
Abbreviation: Neurogranin Ng RC3 NRGN
Swiss Prot: Q92686 Human, P60761 Mouse, Q04940 Rat
Cellular Locus: Cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human Neurogranin aa 1-78 / 78.
Isotype: IgG
Clone: PSH02-96
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IF-Tissue, IHC-Fr
Positive Control: Mouse brain tissue lysate, mouse hippocampus tissue lysate, rat brain tissue lysate, rat hippocampus tissue lysate, rat brain tissue, mouse brain tissue, mouse hippocampus tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IHC-P: 1:500 ;IF-Tissue: 1:200 ;IHC-Fr: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 8 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96]?

The catalog number for Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96] is HA721915.

What sizes are available for Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96]?

Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96] is available in the following size(s): 100 µL.

Is Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96] in stock?

Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Neurogranin Recombinant Rabbit Monoclonal Antibody [PSH02-96] used for?

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.