Biotin Conjugated Human CD48 Recombinant Rabbit Monoclonal Antibody [PSH08-37] - Detector

About this product

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells.

Specifications

Catalog number

HA722980B

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Antigen CD48 antibody B cell membrane protein antibody B lymphocyte activation marker BLAST 1 antibody B-cell activation marker antibody B-lymphocyte activation marker BLAST-1 antibody BCM 1 surface antigen antibody BCM1 antibody BCM1 surface antigen antibody BLAST 1 antibody BLAST antibody BLAST1 antibody CD 48 antibody CD48 antibody CD48 antigen (B cell membrane protein) antibody CD48 antigen antibody CD48 molecule antibody CD48 protein antibody CD48_HUMAN antibody hCD48 antibody Leucocyte antigen MEM 102 antibody Leukocyte antigen MEM-102 antibody mCD48 antibody MEM 102 antibody MEM-102 antibody MEM102 antibody Signaling lymphocytic activation molecule 2 antibody SLAM family member 2 antibody SLAMF 2 antibody SLAMF2 antibody TCT.1 antibody

Abbreviation

CD48 antigen B-lymphocyte activation marker BLAST-1 BCM1 surface antigen Leukocyte antigen MEM-102 SLAM family member 2 (SLAMF2) Signaling lymphocytic activation molecule 2 TCT.1 CD48 BCM1, BLAST1

Swiss Prot

P09326 Human

Cellular Locus

Cell membrane. Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human CD48 protein aa 27-220 (HA210906).

Isotype

IgG

Clone

PSH08-37

Conjugation

Biotin-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det), ELISA

Positive Control

Recombinant Human CD48 protein (HA210906).

Concentration

1 mg/mL

Dilution

ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH08-36] to Human CD48 antibody (Capture) (HA722977) and recombinant Human CD48 protein (HA210906) as the standard. The reference range value is 5.5-4000 pg/ml. ;ELISA: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes