CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15]

Catalog number HA721585

Price for HA721585

Size / count 100 µL

About this product

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Specifications

Catalog number: HA721585
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: COREST antibody KIAA0071 antibody Nr2b2 antibody Nuclear receptor coregulator 1 antibody Nuclear receptor subfamily 2 group B member 2 antibody Protein CoREST antibody RCOR antibody Rcor1 antibody RCOR1_HUMAN antibody REST corepressor 1 antibody Retinoic acid receptor RXR-beta antibody Retinoid X receptor beta antibody Rxrb antibody
Abbreviation: RCOR1, KIAA0071, RCOR
Swiss Prot: Q9UKL0 Human, Q8CFE3 Mouse, P49743 Rat
Cellular Locus: Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human CoREST aa 1-50 / 485.
Isotype: IgG
Clone: JE35-15
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: K-562 cell lysate, Jurkat cell lysate, MCF7 cell lysate, HeLa cell lysate, HepG2 cell lysate, A549 cell lysate, U-2 OS cell lysate, HT-29 cell lysate, human appendix tissue, human testis tissue, mouse brain tissue, rat colon tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:200-1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 65 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15]?

The catalog number for CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15] is HA721585.

What sizes are available for CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15]?

CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15] is available in the following size(s): 100 µL.

Is CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15] in stock?

CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15] is currently made to order / not held in immediate stock. Contact us for lead time.

What is CoREST Recombinant Rabbit Monoclonal Antibody [JE35-15] used for?

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.