Purified Anti-Human CD340 Antibody[SER4]

Specifications

Catalog number

AN003530P-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

Abbreviation

CD340

Gene ID

2064

UniProt

P04626

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD340 protein

Target

TKR; ERBB; erb-b2 receptor tyrosine kinase; Receptor tyrosine-protein kinase erbB; Tyrosine kinase-type cell surface receptor HER; HER2/ErbB; HER; MLN; ERBB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1; erb-b2 receptor tyrosine kinase 2; HER2/ErbB2; MLN19; Metastatic lymph node gene 19 protein; p185; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; Neu; erb-B2; CD340; erb-b2 receptor tyrosine kinase 2; HER2; HER-2; HER-2/neu; MLN 19; MLN19; NGL; TKR1; C erb B2/neu protein; CD340 antigen; Cerb B2/neu protein; CerbB2; ENV; ENVW; Erb b2 receptor tyrosine kinase 2; ERVWE1; HER 2; HER 2/NEU; Herstatin; HERV7Q; HERV-7q; HERVW; HERVWENV; HERV-W-ENV; Human epidermal growth factor receptor 2; NEU proto oncogene; neuro/glioblastoma derived oncogene homolog; neuro/glioblastoma derived oncogene homolog (avian) ; Neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; Proto-oncogene c-ErbB-2; Tyrosine kinase type cell surface receptor HER2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) ; V erb b2 avian erythroblastic leukemia viral oncoprotein 2; V erb b2 erythroblastic leukemia viral oncogene homolog 2; Verb b2 erythroblastic leukemia viral oncogene homolog 2

Clonality

Monoclonal

Clone

SER4

Conjugation

Unconjugated

Applications

FCM

Field of Research

Tags & Cell Markers; Signal Transduction; Cancer

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Isotype

Mouse IgG2b, κ