Recombinant Human GDF2 Protein (His Tag)

Specifications

Catalog number

PDEH101121-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

BMPs belong to the TGF-β superfamily, which currently has over 20 members. BMPs play a vital role in several processes, such as embryogenesis and tissue homeostasis; thus, they are also known as body morphogenetic proteins.9 BMP2, BMP6 and BMP7 are deeply involved in inflammatory disorders, including fibrosis, inflammatory bowel disease, ankylosing spondylitis, and rheumatoid arthritis. BMP9 is considered a unique member of the BMP family as it has the strongest osteogenic effect on mesenchymal stem cells (MSCs), is resistant to the BMP signaling inhibitors, noggin and BMP3, nd significantly affects vascular homeostasis, angiogenesis, metabolism, neurogenesis, and pro- or anti-tumorigenesis.

Abbreviation

GDF2

Synonyms

Bone morphogenetic protein 9; BMP-9; Growth/differentiation factor 2

UniProt

Q9UK05

Accession Number

Q9UK05

Expression System

E.coli

Tag

N-His

Sequence

Ser320-Arg429

Field of Research

Developmental Biology; Cardiovascular; Signal Transduction

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

11.9 kDa

Observed Molecular Weight

12 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human