Alpha-Synuclein Recombinant Rabbit Monoclonal Antibody [PSH08-83]

About this product

Alpha-synuclein (aSyn) is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function. In Parkinson's disease and other synucleinopathies, insoluble forms of alpha-synuclein accumulate as inclusions in Lewy bodies. Familial Parkinson's disease is associated with mutations in the -synuclein (SNCA) gene. In the process of seeded nucleation, alpha-synuclein acquires a cross-sheet structure similar to other amyloids.

Specifications

Catalog number

HA723035

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Alpha synuclein antibody Alpha-synuclein antibody Alpha-synuclein, isoform NACP140 antibody alphaSYN antibody MGC105443 antibody MGC110988 antibody MGC127560 antibody MGC64356 antibody NACP antibody Non A beta component of AD amyloid antibody Non A4 component of amyloid antibody Non A4 component of amyloid precursor antibody Non-A beta component of AD amyloid antibody Non-A-beta component of alzheimers disease amyloid , precursor of antibody Non-A4 component of amyloid precursor antibody Non-A4 component of amyloid, precursor of antibody OTTHUMP00000218549 antibody OTTHUMP00000218551 antibody OTTHUMP00000218552 antibody OTTHUMP00000218553 antibody OTTHUMP00000218554 antibody PARK 1 antibody PARK 4 antibody PARK1 antibody PARK4 antibody Parkinson disease (autosomal dominant, Lewy body) 4 antibody Parkinson disease familial 1 antibody SNCA antibody Snca synuclein antibody Snca synuclein, alpha (non A4 component of amyloid precursor) antibody SYN antibody Synuclein alpha antibody Synuclein alpha 140 antibody Synuclein, alpha (non A4 component of amyloid precursor) antibody SYUA_HUMAN antibody

Abbreviation

Alpha-synuclein Non-A beta component of AD amyloid Non-A4 component of amyloid precursor (NACP) SNCA NACP, PARK1

Swiss Prot

P37840 Human, O55042 Mouse, P37377 Rat

Cellular Locus

Cytoplasm, Membrane, Nucleus, Synapse, Secreted, Cell projection, axon.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human Alpha-Synuclein aa 1-140.

Isotype

IgG

Clone

PSH08-83

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IHC-Fr, IF-Tissue

Positive Control

Mouse cerebellum tissue, rat cerebellum tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000 ;IHC-P: 1:5,000 ;IHC-Fr: 1:500 ;IF-Tissue: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 14 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes