RAP1A + RAP1B Recombinant Rabbit Monoclonal Antibody [JE35-61]

About this product

RAP1A: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. RAP1B: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.

Specifications

Catalog number

HA721335

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C21KG antibody G 22K antibody G-22K antibody GTP binding protein smg p21A antibody GTP-binding protein smg p21A antibody KREV 1 antibody KREV1 antibody OTTHUMP00000013741 antibody RAP 1A antibody RAP1 antibody RAP1A antibody RAP1A member of RAS oncogene family antibody RAP1A_HUMAN antibody Ras related protein Krev 1 antibody Ras related protein Rap 1A antibody RAS related protein RAP1A antibody Ras-related protein Krev-1 antibody Ras-related protein Rap-1A antibody SMGP21 antibody GTP-binding protein smg p21B antibody K-REV antibody OK/SW-cl.11 antibody RAL1B antibody rap1b antibody RAP1B member of RAS oncogene family antibody RAP1B_HUMAN antibody Ras family small GTP binding protein RAP1B antibody RAS related protein RAP1B antibody Ras-related protein Rap-1b antibody Small GTP binding protein antibody

Abbreviation

RAP1A, RAP1B

Swiss Prot

P62834 Human, P61224 Human, P62835 Mouse, Q99JI6 Mouse

Cellular Locus

Cell membrane, Cytoplasm, Cytoplasm, perinuclear region, Cell junction, Early endosome; Cell membrane, Cytoplasm, cytosol, Cell junction.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human RAP1A aa 93-142 / 184.

Isotype

IgG

Clone

JE35-61

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC

Positive Control

HeLa cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, HEK-293 cell lysate, HEK-293.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 20 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes