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![Biotin Conjugated Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c90061270361ea828a6/imageurl/ha721611.webp)
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Product details
Catalog number HA721611
Price for HA721611
Size / count 100 µL
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
The catalog number for Biotin Conjugated Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) is HA721611.
Biotin Conjugated Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) is available in the following size(s): 100 µL.
Biotin Conjugated Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) is currently made to order / not held in immediate stock. Contact us for lead time.
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promo
Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.
Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.
Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.
