Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54]

Catalog number HA721833

Price for HA721833

Size / count 100 µL

About this product

Platelet Derived Growth Factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PDGF-AA, PDGF-AB, and PDGF-BB. These three isoforms bind with different affinities to two receptor types, a and b, which are endowed with protein tyrosine kinase domains and undergo either homo- or heterodimerization as a consequence of ligand binding. Ligand stimulation of PDGFR-b leads to autophosphorylation at Tyr-857, which is the major autophosphorylation site, and Tyr-751, which is the major in vitro phosphorylation site. Autophosphorylation of Tyr-751, which lies in the kinase insert region, is required for binding of phosphatidylinositol-3 kinase to the receptor. These auto-phosphorylation events largely contribute to signal transduction through the PDGF receptor. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.

Specifications

Catalog number: HA721833
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Beta platelet derived growth factor receptor antibody Beta-type platelet-derived growth factor receptor antibody CD 140B antibody CD140 antigen-like family member B antibody CD140b antibody CD140b antigen antibody IBGC4 antibody IMF1 antibody JTK12 antibody OTTHUMP00000160528 antibody PDGF R beta antibody PDGF-R-beta antibody PDGFR 1 antibody PDGFR antibody PDGFR beta antibody PDGFR1 antibody PDGFRB antibody PGFRB_HUMAN antibody Platelet derived growth factor receptor 1 antibody Platelet derived growth factor receptor beta antibody Platelet derived growth factor receptor beta polypeptide antibody
Abbreviation: PDGF-R-beta, PDGFR-beta, PDGFR-1, PDGFRB, Pdgfrb
Swiss Prot: P05622 Mouse
Cellular Locus: Cell membrane, Cytoplasmic vesicle.
Host: Rabbit
Species Reactivity: Mouse, Rat, Human
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Tyr1021 of human PDGFR beta.
Isotype: IgG
Clone: JE48-54
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: NIH/3T3 treated with 100 ng/mL PDGF for 5 minutes whole cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 124 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54]?

The catalog number for Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54] is HA721833.

What sizes are available for Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54]?

Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54] is available in the following size(s): 100 µL.

Is Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54] in stock?

Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Phospho-PDGFR beta (Y1021) Recombinant Rabbit Monoclonal Antibody [JE48-54] used for?

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.