Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture)

Catalog number HA721606

Price for HA721606

Size / count 100 µL

About this product

Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance.

Specifications

Catalog number: HA721606
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CTLA 8 antibody CTLA-8 antibody CTLA8 antibody cytotoxic T lymphocyte associated antigen 8 antibody Cytotoxic T lymphocyte associated protein 8 antibody Cytotoxic T lymphocyte associated serine esterase 8 antibody Cytotoxic T-lymphocyte-associated antigen 8 antibody IL 17 antibody IL 17A antibody IL-17 antibody IL-17A antibody IL17 antibody IL17_HUMAN antibody Il17a antibody Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody interleukin 17A antibody Interleukin-17A antibody interleukin17 antibody Interleukin17A antibody OTTHUMP00000016597 antibody OTTMUSP00000046003 antibody
Abbreviation: Interleukin-17A IL-17 IL-17A Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8) Il17a Ctla8 Il17
Swiss Prot: Q62386 Mouse
Cellular Locus: Secreted.
Host: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant protein within mouse IL17A 26-158.
Isotype: IgG
Clone: PS01-91
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Cap)
Concentration: 1 mg/mL
Dilution: ELISA (Cap): Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Molecular Weight: Predicted band size: 18 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture)?

The catalog number for Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture) is HA721606.

What sizes are available for Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture)?

Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture) is available in the following size(s): 100 µL.

Is Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture) in stock?

Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.

What is Mouse IL-17A Recombinant Rabbit Monoclonal Antibody [PS01-91] - BSA and Azide free (Capture) used for?

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.