pro Caspase 10 Recombinant Rabbit Monoclonal Antibody [JE59-42]

About this product

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. That protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Specifications

Catalog number

HA722029

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Apoptotic protease Mch4 antibody CASP10 antibody Caspase 10 antibody FLICE2 antibody ICE like apoptotic protease 4 antibody

Abbreviation

CASP10, MCH4

Swiss Prot

Q92851 Human

Cellular Locus

Cytoplasm, cytosol, ripoptosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Caspase 10 aa 181-280 / 521.

Isotype

IgG

Clone

JE59-42

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

HepG2 cell lysate, A431 cell lysate, K-562 cell lysate, human breast cancer tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 59 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes