Syndecan 4 Recombinant Rabbit Monoclonal Antibody [PSH0-72]

About this product

Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan-4 interacts with extracellular matrix, anticoagulants, and growth-factors. It also regulates the actin cytoskeleton, cell adhesion, and cell migration. Syndecan-4 activates protein kinase C (PKC), an enzyme involved in signal transduction. The variable domain of syndecan-4 could be a site of self-association. The degree of oligomerization correlates with the activity of kinases, so the degree of clustering of syndecan-4 correlates to PKC activity. Syndecan-4 also binds to phosphatidylinositol (4,5)-bisphosphate (PIP2) through the variable domain and increases PKC activity ten-fold. Syndecan-4 is also a regulator of fibroblast growth factor-2 (FGF-2) signaling. Syndecan-4 binds to FGF and mediates interaction with the FGF receptor. Because the tight correlation between syndecan-4 and growth factors, the efficiency of angiogenic therapies have been thought to relate to syndecan-4. Growth factor signaling may be disrupted by changes in syndecan-4 expression. The cellular uptake, trafficking, and nuclear localization of FGF-2 could be increased by co-delivery of syndecan-4 proteoliposomes. These alterations should be considered in FGF-2-based therapies. Syndecan-4 is also associated with the healing process. Lack of Sdc4 gene causes delayed wound healing in mice. This delay may be due to compromised fibroblast motility.

Specifications

Catalog number

HA721473

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Amphiglycan antibody MGC22217 antibody OTTHUMP00000031788 antibody ryudocan amphiglycan antibody Ryudocan antibody Ryudocan core protein antibody SDC 4 antibody Sdc4 antibody SDC4_HUMAN antibody SYND 4 antibody SYND4 antibody syndecan 4 antibody syndecan 4 (amphiglycan, ryudocan) antibody syndecan proteoglycan 4 antibody Syndecan-4 antibody Syndecan4 antibody

Abbreviation

SDC4

Swiss Prot

P31431 Human

Cellular Locus

Membrane, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human Syndecan 4 Extracellular.

Isotype

IgG

Clone

PSH0-72

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

HepG2 cell lysate, Jurkat cell lysate, HeLa cell lysate, U-87 MG cell lysate, A549 cell lysate, MCF7 cell lysate, MDA-MB-231 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 22 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes