Purified Anti-Human CD22 Antibody[LL2]

Specifications

Catalog number

AN007540P-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or Blymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.

Abbreviation

CD22

Gene ID

933

UniProt

P20273

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD22 protein

Target

Lyb; SIGLEC2FLJ; B-cell receptor CD; T-cell surface antigen Leu; sialic acid binding Ig-like lectin; Sialic acid-binding Ig-like lectin; CD22; SIGLEC-2; SIGLEC2; B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; Lyb-8; sialic acid binding Ig-like lectin 2; Sialic acid-binding Ig-like lectin 2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14; Siglec-2; CD22 molecule; B cell receptor CD22 precursor; B lymphocyte cell adhesion molecule; BL CAM; BLCAM; CD 22; CD22 antigen; CD22 protein; Lectin 2; Leu14; Lyb8; MGC130020; sialic acid binding Ig like lectin 2; Sialic acid binding immunoglobulin like lectin 2; SIGLEC 2; T cell surface antigen Leu 14

Clonality

Monoclonal

Clone

LL2

Conjugation

Unconjugated

Applications

FCM

Field of Research

Immunology; Cancer; Stem Cells

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Isotype

Mouse IgG2a, κ