CD98 Mouse Monoclonal Antibody [A9D7]

About this product

Component of several heterodimeric complexes involved in amino acid transport. The precise substrate specificity depends on the other subunit in the heterodimer. The complexes function as amino acid exchangers. The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids. The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane. The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine. When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier. The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals. Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier.

Specifications

Catalog number

HA601125

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

4F2 antibody 4F2 cell surface antigen heavy chain antibody 4F2 cell-surface antigen heavy chain antibody 4F2 heavy chain antibody 4F2 heavy chain antigen antibody 4F2_HUMAN antibody 4F2hc antibody 4T2HC antibody Antigen defined by monoclonal antibody 4F2 heavy chain antibody Antigen identified by monoclonal antibodies 4F2 TRA1.10 TROP4 and T43 antibody CD 98 antibody CD98 antibody CD98 antigen antibody CD98 heavy chain antibody CD98HC antibody Heavy chain antibody Lymphocyte activation antigen 4F2 large subunit antibody MDU 1 antibody MDU1 antibody Monoclonal antibody 44D7 antibody NACAE antibody Slc3a2 antibody Solute carrier family 3 (activators of dibasic and neutral amino acid transport) member 2 antibody Solute carrier family 3 member 2 antibody

Abbreviation

4F2 cell-surface antigen heavy chain 4F2hc 4F2 heavy chain antigen Lymphocyte activation antigen 4F2 large subunit Solute carrier family 3 member 2 CD98 SLC3A2 MDU1

Swiss Prot

P08195 Human

Cellular Locus

Apical cell membrane, Cell membrane, Cell junction, Lysosome membrane.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human CD98 aa 450-630 (Extracellular).

Isotype

IgG2b

Clone

A9D7

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

A431 cell lysate, Hela cell lysate, HepG2 cell lysate, human skin tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No