Biotin Conjugated Human IFNGR1 Recombinant Rabbit Monoclonal Antibody [PSH06-44]

About this product

Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1. A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas.

Specifications

Catalog number

HA722681B

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Antiviral Protein Type II antibody Antiviral protein, type 2 antibody AVP type II antibody AVP, type 2 antibody CD 119 antibody CD119 antibody CD119 antigen antibody CDw119 antibody FLJ45734 antibody IFN gamma R alpha antibody IFN gamma R antibody IFN gamma R1 antibody IFN-gamma receptor 1 antibody IFN-gamma-R1 antibody IFNG R1 antibody IFNGR 1 antibody IFNGR antibody IFNGR1 antibody Immune interferon receptor 1 antibody Immune interferon receptor for antibody INGR1_HUMAN antibody Interferon gamma receptor 1 antibody Interferon gamma receptor alpha chain antibody Interferon gamma receptor alpha chain precursor antibody

Abbreviation

Interferon gamma receptor 1 IFN-gamma receptor 1 IFN-gamma-R1 CDw119 Interferon gamma receptor alpha-chain IFN-gamma-R-alpha CD119 IFNGR1

Swiss Prot

P15260 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human IFNGR1 aa 18-245.

Isotype

IgG

Clone

PSH06-44

Conjugation

Biotin-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det)

Positive Control

Recombinant standard Human IFNGR1 protein (HA210514).

Concentration

1 mg/mL

Dilution

ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH06-43] to Human IFNGR1 antibody (Capture) (HA722679) and recombinant standard Human IFNGR1 protein (HA210514) as the standard. The reference range value is 41.2-10,000 pg/ml.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes