GC1q R Recombinant Mouse Monoclonal Antibody [A8F4-R]

About this product

Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria.

Specifications

Catalog number

HA601173

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ASF/SF2 associated protein p32 antibody C1q globular domain binding protein antibody C1qBP antibody C1QBP_HUMAN antibody Complement component 1 q subcomponent binding protein antibody Complement component 1 Q subcomponent binding protein mitochondrial antibody Complement component 1 Q subcomponent-binding protein, mitochondrial antibody GC1Q R antibody GC1q R protein antibody GC1q-R protein antibody GC1QBP antibody GC1QR antibody globular domain of, C1q, receptor for antibody Glycoprotein gC1qBP antibody HABP 1 antibody HABP1 antibody Hyaluronan binding protein 1 antibody Hyaluronan-binding protein 1 antibody Mitochondrial matrix protein p32 antibody p32 antibody p32 splicing factor antibody p33 antibody Pre mrna splicing factor SF2 P32 subunit precursor antibody SF2p32 antibody Splicing factor SF2 associated protein antibody

Abbreviation

Complement component 1 Q subcomponent-binding protein, mitochondrial ASF/SF2-associated protein p32 Glycoprotein gC1qBP C1qBP Hyaluronan-binding protein 1 Mitochondrial matrix protein p32 gC1q-R protein p33 SF2AP32 C1QBP GC1QBP HABP1 SF2P32

Swiss Prot

Q07021 Human, O35658 Mouse, O35796 Rat

Cellular Locus

Extracellular region or secreted, Nucleus, Plasma membrane, Cytoplasm, Mitochondrion.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human GC1q R aa 100-282.

Isotype

IgG1

Clone

A8F4-R

Conjugation

Non-conjugated

Type

Recombinant Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

HeLa cell lysate, K-562 cell lysate, MCF7 cell lysate, A549 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, rat spleen tissue lysate, mouse spleen tissue lysate, human colon tissue, human kidney tissue, mouse colon tissue, HeLa.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:1,000-1:5,000 ;IF-Cell: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 31 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes