LSD2 Recombinant Rabbit Monoclonal Antibody [JE32-40]

About this product

Lysine (K)-specific demethylase 1B is a protein that in humans is encoded by the KDM1B gene. Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function. Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes.

Specifications

Catalog number

HA721462

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

amine oxidase (flavin containing) domain 1 antibody amine oxidase, flavin containing 1 antibody AOF1 antibody bA204B7.3 antibody C6orf193 antibody dJ298J15.2 antibody Flavin-containing amine oxidase domain-containing protein 1 antibody FLJ33898 antibody FLJ34109 antibody FLJ43328 antibody KDM1B antibody KDM1B_HUMAN antibody LSD2 antibody lysine (K)-specific demethylase 1B antibody Lysine-specific demethylase 2 antibody Lysine-specific histone demethylase 1B antibody Lysine-specific histone demethylase 2 antibody

Abbreviation

KDM1B, AOF1, C6orf193, LSD2

Swiss Prot

Q8NB78 Human

Cellular Locus

Nucleus, Chromosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human LSD2 aa 71-120 / 822.

Isotype

IgG

Clone

JE32-40

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

HeLa cell lysate, Jurkat cell lysate, A549 cell lysate, K-562 cell lysate, MCF7 cell lysate, U-2 OS cell lysate, HCT 116 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 92 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes