EPO-R Rabbit Polyclonal Antibody

Catalog number HA500529

Price for HA500529

Size / count 100 µL

About this product

The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers. These dimers were originally thought to be formed by extracellular domain interactions, however, it is now assumed that it is formed by interactions of the transmembrane domain and that the original structure of the extracellular interaction site was due to crystallisation conditions and does not depict the native conformation. Binding of a 30 kDa ligand erythropoietin (Epo), changes the receptor's conformational change, resulting in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity). At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis.

Specifications

Catalog number: HA500529
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: EPO R antibody EPO Receptor antibody EPO-R antibody epor antibody EPOR_HUMAN antibody Erythropoietin receptor antibody Erythropoietin receptor precursor antibody MGC138358 antibody
Abbreviation: EPOR
Swiss Prot: P19235 Human
Cellular Locus: Cell membrane; Secreted.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human EPO-R aa 351-400 / 508.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB
Positive Control: K-562 cell lysate, HepG2 cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 55 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for EPO-R Rabbit Polyclonal Antibody?

The catalog number for EPO-R Rabbit Polyclonal Antibody is HA500529.

What sizes are available for EPO-R Rabbit Polyclonal Antibody?

EPO-R Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is EPO-R Rabbit Polyclonal Antibody in stock?

EPO-R Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is EPO-R Rabbit Polyclonal Antibody used for?

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.