CD35 Recombinant Mouse Monoclonal Antibody [A4G1-R]

About this product

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

Specifications

Catalog number

HA601250

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C3 binding protein antibody C3b/C4b receptor antibody C3BR antibody C4BR antibody CD 35 antibody CD35 antibody CD35 antigen antibody complement component (3b/4b) receptor 1 (Knops blood group) antibody complement component (3b/4b) receptor 1 including Knops blood group system antibody Complement component receptor 1 antibody Complement receptor 1 antibody Complement receptor type 1 antibody CR 1 antibody CR1 antibody CR1_HUMAN antibody KN antibody Knops blood group antigen antibody

Abbreviation

Complement receptor type 1 C3b/C4b receptor CD35

Swiss Prot

P17927 Human

Cellular Locus

Membrane.

Host

Mouse

Species Reactivity

Human

Immunogen

Synthetic peptide within C-terminal human CD35.

Isotype

IgG1

Clone

A4G1-R

Conjugation

Non-conjugated

Type

Recombinant Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Tissue

Positive Control

TF-1 cell lysate, human kidney tissue lysate, human hodgkin lymphoma tissue, human kidney tissue, human small intestine tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IHC-P: 1:500-1:2,000 ;IF-Tissue: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 224 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes