Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20]

Catalog number HA722245

Price for HA722245

Size / count 100 µL

About this product

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, is comprised of ICE, CPP32, ICH-1/Nedd-2, Tx, Mch2, Mch3 (ICE-LAP3 or CMH-1), Mch4 and ICE-LAP6. Ced-3/ICE family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology. The nuclear Lamin A is cleaved by Mch2, but not CPP32. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family. Lamin C is a splice variant of Lamin A, differing only at the carboxy-terminus. Lamins A and C are identical for the first 566 amino acids, with Lamin C differing only in six unique carboxy-terminal amino acids.

Specifications

Catalog number: HA722245
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 70 kDa lamin antibody Cardiomyopathy dilated 1A (autosomal dominant) antibody CDCD1 antibody CDDC antibody CMD1A antibody CMT2B1 antibody EMD2 antibody FPL antibody FPLD antibody FPLD2 antibody HGPS antibody IDC antibody Lamin A antibody Lamin A/C antibody Lamin A/C like 1 antibody Lamin antibody Lamin C antibody Lamin-A/C antibody LDP1 antibody LFP antibody LGMD1B antibody Limb girdle muscular dystrophy 1B (autosomal dominant) antibody LMN 1 antibody LMN A antibody LMN C antibody LMN1 antibody LMNA antibody LMNA_HUMAN antibody LMNC antibody LMNL1 antibody Prelamin A/C antibody PRO1 antibody Renal carcinoma antigen NY REN 32 antibody Renal carcinoma antigen NY-REN-32 antibody Renal carcinoma antigen NYREN32 antibody
Abbreviation: LMNA, LMN1
Swiss Prot: P02545 Human, P48678 Mouse, P48679 Rat
Cellular Locus: Intermediate filament, Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide.
Isotype: IgG
Clone: PSH05-20
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: HeLa cell lysate, HepG2 cell lysate, HeLa, human breast tissue, human skin tissue, human colon tissue, mouse colon tissue, rat colon tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IF-Cell: 1:200 ;IHC-P: 1:200-1:5,000 ;FC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 74 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20]?

The catalog number for Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20] is HA722245.

What sizes are available for Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20]?

Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20] is available in the following size(s): 100 µL.

Is Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20] in stock?

Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20] used for?

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.