MIγ/CXCL9 Polyclonal Antibody

Specifications

Catalog number

D-AB-10440L-01

Size / count

25 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as Monokine induced by gamma interferon (MIG), is a small cytokine belonging to the CXC chemokine family. The function of this chemokine has not been specifically defined; however, it is thought to be involved in T cell trafficking. CXCL9/MIG functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. CXCL9/MIG, together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all, and CXCL10 in most melanoma metastases. Experiment data represent novel mechanisms by which tumour cells in melanoma metastases might use the chemokine-expressing endothelium to leave the tumour and eventually to form additional metastases at distinct sites. Experiment results also improved that CXCL9/MIG plays an important role in CD4+ T lymphocyte recruitment and development of CAV, MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9/MIG, and recipient CD4 lymphocytes are necessary for sustained CXCL9/MIG production and CAV development in this model. Neutralization of the chemokine CXCL9/MIG may have therapeutic potential for the treatment of chronic rejection after heart transplantation.

Abbreviation

MIγ/CXCL9

UniProt

P18340

Host

Rabbit

Reactivity

Mouse; Rat

Immunogen

Recombinant Mouse MIγ/CXCL9 protein expressed by E.coli

Target

C-X-C motif chemokine 9; Gamma-interferon-induced monokine; Monokine induced by interferon-gamma (MIG; MuMIG) ; Protein m119; Small-inducible cytokine B9; Cxcl9; Mig; Scyb9

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB

Field of Research

Epigenetics and Nuclear Signaling; Cancer; CellBiology; Neuroscience; Signal Transduction; Developmental Biology; Immunology

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

14 kDa

Observed Molecular Weight

15 kDa

Isotype

IgG