EGF Polyclonal Antibody

Catalog number AN007200L-01

Discontinued

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Size / count 25 µL

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Specifications

Catalog number: AN007200L-01
Size / count: 25 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Epidermal growth factor (EGF) is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin-binding EGF-like growth factor (HB-EGF), epigen, and the neuregulins (NRG) -1 through -6. Members of the EGF family share a structural motif, the EGF-like domain, which is characterized by three intramolecular disulfide bonds that are formed by six similarly spaced conserved cysteine residues. All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis. The 1207 amino acid (aa) human EGF precursor contains nine EGF domains and nine LDLR class B repeats. The mature protein consists of 53 aa and is generated by proteolytic excision of the EGF domain proximal to the transmembrane region. Mature human EGF shares 70% aa sequence identity with mature mouse and rat EGF. EGF is present in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid. Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members. These receptors undergo a complex pattern of ligand induced homo- or hetero-dimerization to transduce EGF family signals . EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2. Dimerization results in autophosphorylation of the receptor at specific tyrosine residues to create docking sites for a variety of signaling molecules. Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.
Abbreviation: EGF
UniProt: P01133
Host: Rabbit
Reactivity: Rat
Immunogen: Recombinant Human EGF protein expressed by Mammalian
Target: HOMG; EGF; HOMG4; URG; Beta urogastrone; beta-urogastrone; Epidermal growth factor; OTTHUMP00000219721; OTTHUMP00000219722; Pro epidermal growth factor; Pro-Epidermal Growth Factor; Urogastrone
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB
Field of Research: Signal Transduction; Cell Biology; Cancer; Kits; Lysates; Other
Purification: Antigen Affinity Purification
Concentration: 1 mg/mL
Dilution: WB 1:500-1:1000
Buffer: PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 133 kDa
Observed Molecular Weight: 80 kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for EGF Polyclonal Antibody?

The catalog number for EGF Polyclonal Antibody is AN007200L.

What sizes are available for EGF Polyclonal Antibody?

EGF Polyclonal Antibody is available in the following size(s): 25 µL, 100 µL.

How many pack sizes does EGF Polyclonal Antibody come in?

EGF Polyclonal Antibody is available in 2 different pack sizes.

Is EGF Polyclonal Antibody in stock?

EGF Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EGF Polyclonal Antibody?

EGF Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for EGF Polyclonal Antibody?

Estimated delivery time for EGF Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for EGF Polyclonal Antibody?

The safety data sheet for EGF Polyclonal Antibody is available here: https://789.bio/ea/xSl1VH.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.