PE/Cyanine7 Anti-Mouse CD45R (B220) Antibody[RA3-6B2]

Specifications

Catalog number

AN00428UH-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker. CD19, however, may be more appropriate for B cell specificity.

Abbreviation

CD45R

Gene ID

19264;5788

UniProt

Q64224

Host

Rat

Reactivity

Mouse

Target

CD45R; B220

Clonality

Monoclonal

Clone

RA3-6B2

Conjugation

PE/Cyanine 7

Applications

FCM

Concentration

0.2 mg/mL

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ