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![Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea82050/imageurl/ha721610.webp)
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Product details
Catalog number HA721610
Price for HA721610
Size / count 100 µL
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
The catalog number for Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) is HA721610.
Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) is available in the following size(s): 100 µL.
Rat IL-1 beta Recombinant Rabbit Monoclonal Antibody [PS01-87] - BSA and Azide free (Detector) is currently made to order / not held in immediate stock. Contact us for lead time.
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promo
Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.
Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
