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Product details

Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42]

Catalog number HA722146

Price for HA722146

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Size / count 100 µL

About this product

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene. Serine/threonine-protein kinase PAK 5 is an enzyme that in humans is encoded by the PAK5 gene. Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene. PAK4 is one of six members of the PAK family of serine/threonine kinases which are divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7). PAK4 localizes in sub-cellular domains of the cytoplasm and nucleus. PAK4 regulates cytoskeleton remodeling, phenotypic signaling and gene expression, and affects directional motility, invasion, metastasis, and growth. Similar to PAK1, PAK4-signaling-dependent cellular functions also regulate both physiologic and disease processes such as cancer, as PAK4 is overexpressed and/or hyperstimulated in human cancer, at-large. The PAK5 enzyme is one of three members of Group II PAK family of serine/threonine kinases, and evolutionary conserved across species. PAK6 belongs to the Group II PAK family members. Like other family members, PAK6 is also evolutionary conserved across species. Phospho-PAK4+PAK5+PAK6 (S474+S560+S602) Antibody detects endogenous levels of PAK4, PAK5 and PAK6 only when phosphorylated at serine 474, 602, or 560, respectively.

Specifications

Catalog number
HA722146
Size / count
100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9000-83-3
Product Name Alternative
KIAA1142 antibody p21 activated kinase 4 antibody p21 Cdc42/Rac1-actiated kinase 4 antibody P21 protein (Cdc42/Rac) activated kinase 4 antibody p21 (CDKN1A) activated kinase 4 antibody p21-activated kinase 4 antibody PAK 4 antibody PAK-4 antibody Pak4 antibody PAK4_HUMAN antibody Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibody Serine threonine kinase PAK 4 antibody Serine/threonine protein kinase PAK 4 antibody Serine/threonine protein kinase PAK4 antibody Serine/threonine-protein kinase PAK 4 antibody EC 2.7.11.1 antibody KIAA1264 antibody MGC26232 antibody p21 activated kinase 7 antibody p21 protein (Cdc42/Rac)-activated kinase 7 antibody p21 (CDKN1A) activated kinase 7 antibody p21-activated kinase 5 antibody p21-activated kinase 7 antibody PAK 5 antibody PAK 7 antibody PAK-5 antibody PAK-7 antibody PAK5 antibody PAK7 antibody PAK7_HUMAN antibody Protein kinase PAK5 antibody Serine/threonine protein kinase PAK 7 antibody Serine/threonine-protein kinase PAK 7 antibody CDKN1A activated kinase 6 antibody EC 2.7.1.37 antibody p21 activated protein kinase 6 antibody p21 protein (Cdc42/Rac)-activated kinase 6 antibody p21 (CDKN1A) activated kinase 6 antibody p21-activated kinase 6 antibody p21activated kinase 6 antibody PAK 6 antibody PAK-6 antibody Pak6 antibody PAK6_HUMAN antibody Serine threonine protein kinase PAK 6 antibody Serine/threonine protein kinase PAK 6 antibody Serine/threonine protein kinase PAK6 antibody Serine/threonine-protein kinase PAK 6 antibody
Abbreviation
PAK4, KIAA1142, PAK5, KIAA1264, PAK7, PAK6
Swiss Prot
O96013 Human, Q9P286 Human, Q9NQU5 Human
Cellular Locus
Cytoplasm; Mitochondrion, Cytoplasm, Nucleus; Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Ser474 of human PAK4.
Isotype
IgG
Clone
JE57-42
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
A549 cell lysate, HeLa cell lysate, MCF7 cell lysate, HUVEC cell lysate, HUVEC treated with 50ng/mL VEGF for 2 minutes cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 64/81/75 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes

Frequently Asked Questions

What is the catalog number for Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42]?

The catalog number for Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42] is HA722146.

What sizes are available for Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42]?

Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42] is available in the following size(s): 100 µL.

Is Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42] in stock?

Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Recombinant Rabbit Monoclonal Antibody [JE57-42] used for?

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene. Serine/threonine-protein kinase PAK 5 is an enzyme that in humans is encoded by the PAK5 gene. Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene. PAK4 is one of

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

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