GMP Human IL-12 Protein

Catalog number GMP-L12H23-500ug

Discontinued

Price for GMP-L12H23-500ug

Size / count 500 µg

This variant is discontinued and cannot be added to your cart.

About this product

GMP Human IL-12 Protein (GMP-L12H23) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 & Arg 23 - Ser 219 (Accession # P29460-1 & P29459-1).

Specifications

Catalog number: GMP-L12H23-500ug
Size / count: 500 µg
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. These effects include inducing production of IFN-gamma and TNF by resting and activated T and NK cells, synergizing with other IFN-gamma inducers at both the transcriptional and post-transcriptional levels. This interaction induces IFN-gamma gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. Current evidence indicates that IL‑12, produced by macrophages in response to infectious agents, is a central mediator of the cell‑mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. In its role as the initiator of cell-mediated immunity, it has been suggested that IL-12 has therapeutic potential as a stimulator of cell-mediated immune responses to microbial pathogens, metastatic cancers, and viral infections such as AIDS.
Specifications: This protein carries no "tag". The protein has a calculated MW of 58.9 kDa. The protein migrates as 76 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expression Region: Ile 23 - Ser 328 & Arg 23 - Ser 219
Host: HEK 293
Target: IL-12B & IL-12A
Conjugation: Unconjugated
Tag: Native
Source: Human
Stability: -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution._x000D_Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin: 10 EU/mg
Purity: 95%
Format: Powder-GMP
Buffer: PBS, pH7.4
Molecular Weight: 58.9 kDa
Shipping Conditions: Blue ice
Storage Conditions: -20°C

Frequently Asked Questions

What is the catalog number for GMP Human IL-12 Protein?

The catalog number for GMP Human IL-12 Protein is GMP-L12H23-500ug.

Is GMP Human IL-12 Protein in stock?

GMP Human IL-12 Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GMP Human IL-12 Protein?

GMP Human IL-12 Protein is manufactured by CRB.

What is the estimated delivery time for GMP Human IL-12 Protein?

Estimated delivery time for GMP Human IL-12 Protein is approximately 10 business day(s), depending on your location.

What is GMP Human IL-12 Protein used for?

GMP Human IL-12 Protein (GMP-L12H23) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 & Arg 23 - Ser 219 (Accession # P29460-1 & P29459-1).

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.