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![SMCC Recombinant Rabbit Monoclonal Antibody [PSH06-06] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea81160/imageurl/ha722505.webp)
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Product details
Catalog number HA722505
Price for HA722505
Size / count 100 µL
Succinimidyl 4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a heterobifunctional amine-to-sulfhydryl crosslinker, which contains two reactive groups at opposite ends: N-hydroxysuccinimide-ester and maleimide, reactive with amines and thiols respectively. SMCC is often used in bioconjugation to link proteins with other functional entities (fluorescent dyes, tracers, nanoparticles, cytotoxic agents). For example, a targeted anticancer agent – trastuzumab emtansine (antibody-drug conjugate containing an antibody trastuzumab chemically linked to a highly potent drug DM-1) – is prepared using SMCC reagent. In a pharmacokinetics study, the CX-DM1-containing ADCs exhibited stability comparable to that of SMCC-DM1-containing ADCs. SMCC is a classic noncleavable linker that has been employed in Kadcyla. However, SMCC-based conjugates are still limited due to their instability in the circulatory system and hydrophobic properties.
The catalog number for SMCC Recombinant Rabbit Monoclonal Antibody [PSH06-06] is HA722505.
SMCC Recombinant Rabbit Monoclonal Antibody [PSH06-06] is available in the following size(s): 100 µL.
SMCC Recombinant Rabbit Monoclonal Antibody [PSH06-06] is currently made to order / not held in immediate stock. Contact us for lead time.
Succinimidyl 4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a heterobifunctional amine-to-sulfhydryl crosslinker, which contains two reactive groups at opposite ends: N-hydroxysuccinimide-ester and maleimide, reactive with amines and thiols respectively. SMCC is often used in bioconjugati
We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.
Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.
Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.
