PMCA1 Recombinant Rabbit Monoclonal Antibody [JE34-05]

About this product

Plasma membrane calcium-transporting ATPase 1 also known as Plasma membrane calcium pump isoform 1 is a plasma membrane Ca2+ ATPase, an enzyme that in humans is encoded by the ATP2B1 gene. It's a transport protein, a translocase, a calcium pump EC 7.2.2.10. The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues.

Specifications

Catalog number

HA722186

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AT2B1_HUMAN antibody ATP2B1 antibody ATPase Ca++ transporting plasma membrane 1 antibody Plasma membrane calcium ATPase 1 antibody Plasma membrane calcium ATPase isoform 1 antibody Plasma membrane calcium pump isoform 1 antibody Plasma membrane calcium transporting ATPase 1 antibody Plasma membrane calcium-transporting ATPase 1 antibody PMCA 1 antibody PMCA1 antibody

Abbreviation

ATP2B1, PMCA1

Swiss Prot

P20020 Human, G5E829 Mouse, P11505 Rat

Cellular Locus

Cell membrane, Basolateral cell membrane, Synapse, Presynaptic cell membrane, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human PMCA1 aa 1,081-1,180 / 1,220.

Isotype

IgG

Clone

JE34-05

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

A549 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, human lung tissue, human stomach tissue, human brain tissue, mouse brain tissue, rat brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:200-1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 135 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes