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![Phospho-Beta Catenin (S33 + S37) Recombinant Rabbit Monoclonal Antibody [JE59-59] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea81924/imageurl/ha721580.webp)
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Product details
Catalog number HA721580
Price for HA721580
Size / count 100 µL
Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene. Beta-catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues. In cardiac muscle, beta-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. Alterations in the localization and expression levels of beta-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
The catalog number for Phospho-Beta Catenin (S33 + S37) Recombinant Rabbit Monoclonal Antibody [JE59-59] is HA721580.
Phospho-Beta Catenin (S33 + S37) Recombinant Rabbit Monoclonal Antibody [JE59-59] is available in the following size(s): 100 µL.
Phospho-Beta Catenin (S33 + S37) Recombinant Rabbit Monoclonal Antibody [JE59-59] is currently made to order / not held in immediate stock. Contact us for lead time.
Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene. Beta-catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gen
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