FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R]

Catalog number HA601298

Price for HA601298

Size / count 100 µL

About this product

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERα+ breast cancer, and its expression might identify ERα+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERα− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland. Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.

Specifications

Catalog number: HA601298
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: forkhead box A1 antibody Forkhead box protein A1 antibody FOX A1 antibody FOXA1 antibody FOXA1_HUMAN antibody hepatocyte nuclear factor 3 alpha antibody Hepatocyte nuclear factor 3-alpha antibody HNF 3A antibody HNF-3-alpha antibody HNF-3A antibody HNF3A antibody MGC33105 antibody TCF 3A antibody TCF-3A antibody TCF3A antibody Transcription factor 3A antibody
Abbreviation: FOXA1
Swiss Prot: P55317 Human
Cellular Locus: Nucleus.
Host: Mouse
Species Reactivity: Human
Immunogen: Synthetic peptide within N-terminal human FOXA1.
Isotype: IgG1
Clone: A2E8-R
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: LNCaP cell lysates, LNCaP, human prostate tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 49 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R]?

The catalog number for FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R] is HA601298.

What sizes are available for FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R]?

FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R] is available in the following size(s): 100 µL.

Is FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R] in stock?

FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R] is currently made to order / not held in immediate stock. Contact us for lead time.

What is FOXA1 Recombinant Mouse Monoclonal Antibody [A2E8-R] used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.